Key Facts Superior Discovery: LR-WGS identified over 30% more gene-disrupting mutations compared to traditional short-read sequencing. Complex Rearrangements: The technology uncovered complex genetic “shuffling” that was previously invisible, explaining why some cases of autism appeared to have no clear genetic cause. Functional Insights: By analyzing DNA methylation (chemical tags on DNA), researchers can now see how these mutations turn genes “on” or “off,” specifically in regions like the FMR