Tulane and Mississippi both enter with revenge on their minds, but the Rebels may hold the edge once again as we break down our best bets , picks and predictions for this CFP matchup for Saturday, December 20.

Tulane vs. Mississippi player prop projections from Covers. Our best CFP Round 1 computer picks for December 20, 2025.

It didn't go well for Tulane the first time it met Mississippi this season. Can the Green Wave change things in the playoff? We make our predictions.

Mississippi quarterback Trinidad Chambliss received treatment on the field and was sidelined during the Rebels’ final first-half series on against Tulane in the College Football Playoff.

Tulane participated in its first ever College Football Playoff matchup and did not put its best foot forward, as the 11th seeded Green Wave were slapped by 6th seed Ole Miss 41-10 Saturday night before 68,