Lets take a look at the matchup including a few key stats and trends, the quarterbacks, and the injured. NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, ...

The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, ...

A loss to the Raiders will put the Giants in the driver’s seat for the No. 1 overall pick in April’s NFL Draft.

The Sporting News is tracking live scoring updates and highlights for 49ers vs. Colts on "Monday Night Football." Follow for ...

Three AFC teams will be in full support of the San Francisco 49ers when they take on the Indianapolis Colts on Monday night.

The Chicago Bears pulled off a remarkable 22-16 comeback overtime victory against the Green Bay Packers on Saturday night, in ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

Monday Night Football closes out Week 16 with a huge matchup between the San Francisco 49ers and the Indianapolis Colts.

The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score ...

Eagles kicker Jake Elliott, once among the most reliable in the league, especially from long distance, says his career-worst ...

NFL Week 17 predictions, picks for games this week, including Broncos-Chiefs, Eagles-Bills, Bears-49ers, Rams-Falcons, Ravens ...