The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

San Francisco 49ers linebacker Dee Winters made a huge play in the fourth quarter to finish off the Indianapolis Colts.

Now back as the wily super-veteran, Rivers is pulling out all the tricks. And on this one, it worked to give the Colts an ...

Another win stacked up by the San Francisco 49ers. Their offense lit up the Indianapolis Colts in primetime to get the win ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The tightrope finally snapped inside Lucas Oil Stadium on primetime Monday Night Football as the Indianapolis Colts suffered ...

Brock Purdy was a vastly different quarterback on Monday night against the Colts compared to his prior Monday Night Football ...

Christian McCaffrey accomplished a milestone he hasn't pulled off since 2023 during the 49ers' matchup against the Colts on ...

The Buffalo Bills, Jacksonville Jaguars and Los Angeles Chargers qualified for the AFC playoffs with the Indianapolis Colts’ ...

The Jacksonville Jaguars will have a chance at winning the Super Bowl this season after earning a playoff spot following ...

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers’ final pass ...

San Francisco 49ers running back Christian McCaffery catches a 9-yard touchdown pass from quarterback Brock Purdy.