The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the Indianapolis Colts.

CLEVELAND - This was supposed to be an easy Sunday afternoon for the Buffalo Bills, a team headed to the playoffs facing a 3-11 Cleveland Browns team that can’t wait for yet another horrible season to end.

NFL Week 17 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Philadelphia Eagles and Buffalo Bills.

The Bills midseason addition at punt returner has a chance to be active for the second time since being acquired in November.

The Buffalo Bills are a National Football League team that plays in the AFC East division. The Bills have yet to win a Super Bowl title over the course of their history.

The Buffalo Bills (11-4) got a step closer to clinching a playoff spot with a 23-20 win over the Cleveland Browns (3-12) on Sunday. Running back James Cook led the Bills with 117 yards rushing and two touchdowns. He eclipsed the 100-yard rushing mark for the ninth time this season.

Who do the experts believe will win as the Buffalo Bills visit the Cleveland Browns in Week 16 of the 2025 NFL season?

Buffalo Bills coach Sean McDermott has elected to take a cup half-full approach in defending his defense's deficiencies.

The Bills found a way to their 11th win of the season, in a too-close-for-comfort 23-20 victory over the clearly rebuilding Cleveland Browns on Sunday. The Bills scored the majority of their points on their first three offensive possessions, but could only muster a field goal the rest of the way.