The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago ...

- The Colts' defense had no answers for the 49ers' offense. Christian McCaffrey averaged over 5.0 yards per rush, while Brock ...

Philip Rivers, who came out of a five-year retirement last week to return at 44 years old, nearly matched Purdy ...

The 49ers face the Colts in Indianapolis on Monday. We break down what the game means for the NFL playoff picture.

Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL ...

The San Francisco 49ers hit the road in Week 16 for a “Monday Night Football” showdown with veteran gunslinger Philip Rivers ...

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at ...

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 ...

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night ...

The San Francisco 49ers and Indianapolis Colts take the field for NFL Monday Night Football tonight in Week 16. MNF start ...