Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

snoRNAs were thought simply to guide chemical modifications to rRNAs, but a new technique has revealed a suite of potential functions in protein secretion. A recent research effort from the University ...

Machine-learning platform enables signal peptide-informed discovery of small molecules that selectively inhibit protein secretion allowing for the degradation of disease-related proteins at the point ...

Cell signaling pathways contain a wide range of secreted proteins and cytokines, and correctly quantifying these molecules is critical for basic research and therapeutic development. The role of the ...

Plant cell-based bioproduction systems are known for producing proteins with proper folding and post-translational modifications that have been used in a handful of approved therapeutics. Widespread ...