Because life expectancy and the prevalence of risk factors such as hypertension, obesity and diabetes are rising globally, heart failure (HF) is growing into a major health problem. Impairment of left ...

Heart failure remains a substantial cause of morbidity and mortality. Despite numerous therapeutic advancements over the past decade, there are populations in whom therapy is insufficient, ...

Whether left ventricular (LV) systolic properties are reduced in diastolic heart failure (DHF) remains controversial, because patients with DHF maintain a normal stroke volume and ejection fraction ...

In Part D, designed to support Phase III, dosing was determined by LVOT-G for oHCM and NT-proBNP for nHCM.

It is a common perception that approximately 50% of heart failure (HF) patients present with a normal or near-normal left ventricular (LV) ejection fraction ("HF with preserved systolic function"), ...

Researchers mapped 442,239 single nuclei from nonfailing human hearts to chart how cardiac cells change from fetal ...

Background: Prolonged steady state exercise can lead to a decrease in left ventricular (LV) function as well as promote the release of cardiac troponin T (cTnT). There is limited information on the ...

Increased pulse wave velocity (PWV), which reflects increased arterial stiffness, is reported to be an independent predictor of cardiovascular outcomes 1, 2 and is associated with the presence of ...

Obstructive sleep apnea subjects the failing heart to adverse hemodynamic and adrenergic loads and may thereby contribute to the progression of heart failure. We hypothesized that treatment of ...

Background Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer ...

High output and low output heart failure refer to how much blood your heart pumps to your body with each heartbeat. In both cases, the output is not enough to meet your body’s needs. A diagnosis of ...