When a cell divides, it performs a feat of microscopic choreography—duplicating its DNA and depositing it into two new cells. The spindle is the machinery behind that process: It latches onto ...

Scientists have a solid understanding of what makes up spindles — the cellular machinery that separates chromosomes — but are less certain about how the building blocks of spindles, called ...

Figure 1: Spo12 promotes mitotic exit of cells with misaligned spindles. In this study we investigate how FEAR network, SPOC and polarity-associated factors communicate to assure faithful mitosis. Our ...

Microtubule motor proteins can be either plus end motors or minus end motors depending on the direction of movement. Mitosis requires the trafficking of proteins along microtubules to produce two ...

Production of Ran-guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent ...