Nature

Using cocaine and apomorphine self-administration in rats to measure the pharmacokinetics of competitive dopamine receptor antagonists administered by different routes

Cocaine self-administration behavior in rats is explained by a pharmacokinetic/pharmacodynamic interaction model. This self-administration model represents a ...
Nature

Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors

The opioid crisis remains a pressing public health challenge, with over 2 million Americans affected by opioid use disorder [1]. Over the past 15 years, oxycodone consumption has surged by ~500%, ...