Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday,

Claire Kittle, who is married to 49ers tight end, George Kittle, said it "really hit home" when San Francisco briefly released veteran fullback Kyle Juszczyk before resigning him in March.

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

DFS millionaire Mike McClure shares his top daily fantasy picks and lineup advice for Indianapolis vs. San Francisco on 'Monday Night Football'

The Seahawks’ chances at the one seed are greatly impacted by the outcome of the 49ers game on Monday Night Football.

If the 2025 season has proven anything, it’s that the San Francisco 49ers are extremely fortunate to have two quality quarterbacks on their roster. The 49ers h