Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world. Atherosclerosis, or the buildup of plaque in the ...

Further investigation into the mechanisms of endothelial dysfunction and its role in the pathogenesis of pulmonary arterial hypertension (PAH) may lead to more targeted therapies against the disease.

The endothelium is a cell layer that lines the body’s blood vessels and lymphatic vessels. These cells are necessary to maintain healthy organs, tissues, and overall body function. The cells of the ...

Many cardiovascular diseases, such as atherosclerosis, or 'hardening of the arteries,' correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels.

Microvascular endothelial dysfunction is an early or inductive event that occurs in the development of cardiovascular diseases and associated organ damage. The endothelium is composed of a single ...