Focal adhesions are dynamic multi-protein assemblies that anchor the intracellular actin cytoskeleton to the extracellular matrix, thereby converting mechanical stimuli into biochemical signals.

Focal adhesions are protein assemblies that allow cells to adhere to and interact with their surrounding matrix. DNA repair pathways and other responses to genotoxic stress have been well described, ...

Immunofluorescence image showing S100A11 (green) localization to focal adhesions and actin stress fibers in a HeLa cell. Microtubules are labeled in red. Researchers at Kanazawa University report in ...

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell ...

Researchers from Tokyo Medical and Dental University (TMDU) identify a novel mechanism by which cells adhere more strongly to their surrounding matrix in response to stress Tokyo, Japan – The DNA ...

The adhesion of a cell to a surface is essential for many cellular processes, including the cell cycle. This article will describe recent studies which have expanded our knowledge of the role of focal ...

“Cell migration is required and essential for metazoan development, tissue regeneration and repair, as well as in immune surveillance. Many diseases such as cancer, fibrosis, and inherited ...

Tissue structures are determined by both cell-cell adhesion and cell-matrix adhesion, with the latter describing interactions between cells and the extracellular matrix (ECM). The ECM is the ...

The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted ...

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial Eligible patients whose tumors ...