Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

With the inventions of transmission electron microscopy (TEM) in 1931 and scanning electron microscopy (SEM) shortly after in 1937, scientists gained an unprecedented ultrastructural view of the ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open questions in cell biology. Using cryo-electron microscopy (cryo-EM), Leonid ...

In 1931, physicists Knoll and Ruska unveiled the first electron microscope, revolutionizing science by using magnetic lenses ...

Berkeley Lab and UC Berkeley physicists' new technique offers detailed images of the small molecules and cell structures that ...

TEM works by transmitting a beam of electrons through an ultra-thin specimen. As the electrons interact with the specimen, they are scattered or transmitted, producing an image that is magnified and ...

Ahead of his 60th birthday, Paul A. Midgley, Professor of Materials Science at the University of Cambridge, discussed his life in science. I had a fairly typical upbringing for someone of my ...

Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the ...

Explore how the National Lab of the Rockies uses advanced microscopy, cryogenic workflows, and automation to connect ...

Cryo-EM studies in Science reveal how three human cone opsins distinguish wavelengths and relay visual signals ...