The Los Angeles defense has been excellent this season, but Baker Mayfield is going to show up for a primetime game, especially if he ends up getting Bucky Irving and Chris Godwin back. Even if he doesn't, the Bucs should be able to get to 20+ points in this spot.

The Kansas City Chiefs (5-5) are favored by 3.5 points against the Indianapolis Colts (8-2) on November 23, 2025, starting at 1 p.m. ET, airing on CBS.

Four of NFL.com's five staff members are picking the Chiefs to win.