Mixon isn't expected to play at all this year, per NFL Media. It's a shocking turn of events for someone who was voted to the Pro Bowl in 2024 during his first season in Houston. Texans general manager Nick Caserio was actually asked about Mixon's injury this week, and at the time, he gave an ominous update on the running back's health.

The Texans will take on the Bills on Thursday Night Football this week, looking to build on a two-game winning run. Stroud has not played in either of those wins having sustained a concussion in Week 9. In his place, backup QB David Mills has gone 2-0 for Houston.

Texans star Joe Mixon is unlikely to return to the field for the 2025 season due to a foot injury he suffered this past offseason.

Texans running back Joe Mixon is not expected to return this season because of a foot injury, sources told ESPN.

Thursday will be the 70th nationally televised game in the Texans' 24 seasons. They have a 28-41 record in national TV games. This article originally published at Thursday's Texans-Bills game is a streaming exclusive. How to watch it for free in Houston.

Without Joe Mixon, the running back situation has been in flux. With him out for the season, there is some clarity in Houston at last.

Former Bengals running back Joe Mixon reportedly will end up missing his entire second season with the Texans because of a foot injury.

Texans star Will Anderson Jr. is honoring an organization that helps veterans deal with PTSD for this year's "My Cause, My Cleats" initiative.