There are big stakes and pressure in Week 13 of the college football season. What upsets could happen? Our experts offer their bold predictions.

The Ducks are 10.5-point favorites in the latest Oregon vs. USC odds, while the over/under for total points scored is 59.5, down four points from the opener. Before making any USC vs. Oregon picks, check out the college football predictions from the SportsLine Projection Model .

The Nebraska Huskers face the Penn State Nittany Lions on Saturday, Nov. 22, 2025 at Beaver Stadium in University Park, Pa.

Oregon Ducks injury updates before hosting the USC Trojans in Autzen Stadium. On ESPN's College GameDay, Pete Thamel confirmed that Oregon wide receivers Dakorien Moore and Gary Bryant Jr. will not play against USC.

Stanford can't keep up with Jaron-Keawe Sagapolutele and the California Golden Bears. Cal's spread anchors Andrew Caley's Triple Option and college football best bets for Week 13.

The Saturday college football schedule features crucial matchups for multiple teams, and the latest bet365 bonus code CBSBET365 gives new users $150 in bonus bets after placing a first wager of $5 or more.

Fans can listen live to Oregon vs. USC on SiriusXM. Stream the broadcast on the app or tune in to channel 196 for the Trojans broadcast or channel 84 for the Ducks radio call in vehicles.

A look at where the Oregon Ducks stand in the College Football Playoff rankings after their win over the Minnesota Golden Gophers.