San Francisco 49ers linebacker Dee Winters made a huge play in the fourth quarter to finish off the Indianapolis Colts.

A pair of Offensive Player of the Year candidates face off on Monday Night Football in Week 16, as Christian McCaffrey and the San Francisco 49ers hit the road

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Sunday Night Football game between Chicago Bears and San Francisco 49ers.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the Indianapolis Colts.

Claire Kittle, who is married to 49ers tight end, George Kittle, said it "really hit home" when San Francisco briefly released veteran fullback Kyle Juszczyk before resigning him in March.

San Francisco 49ers defensive coordinator Robert Saleh told ESPN's Nick Wagoner he's not "in a hurry" to return to head coaching amid rumors the former New York Jets leader could be hired away from the Bay Area ahead of the 2026 season.

San Francisco 49ers quarterback Brock Purdy is sparing no expense to help his community during the holiday season. It's a tradition around this time of the year for NFL quarterbacks to give their offensive linemen a little "Christmas bonus.